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Image Search Results
Journal: eLife
Article Title: A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
doi: 10.7554/eLife.22706
Figure Lengend Snippet: ( A ) MPC1 expression levels in TCGA normal colon and colon adenocarcinoma samples harboring truncating mutations in APC upstream of codon 1600. Statistical significance was analyzed using Mann Whitney test. ( B ) ONCOMINE database was analyzed for gene expression alterations in pyruvate metabolism genes in all cancer types. A control group composed of Uniprot random genes was used for comparison. Graph shows percentage of up- and downregulated genes with respect to the total unique analyses for each gene tested for all cancer groups. Statistical significance was analyzed using Mann Whitney test. ( C ) cBioportal analysis to estimate Kaplan-Meier overall survival of TCGA colorectal adenocarcinoma and kidney chromophobe patients with or without alterations in pyruvate metabolism (PM) genes. For B–C , pyruvate metabolism genes used in meta-analyses: MPC1, MPC2, CS, PDK1, PDHA1, PC, PKLR, LDHA, SLC16A1, GYS1 . See also , , . DOI: http://dx.doi.org/10.7554/eLife.22706.017
Article Snippet: Statistical analysis was performed using
Techniques: Expressing, MANN-WHITNEY, Gene Expression, Control, Comparison
Journal: eLife
Article Title: A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
doi: 10.7554/eLife.22706
Figure Lengend Snippet: ( A ) Gene expression levels of pyruvate metabolism genes in TCGA normal colon and colon mucinous adenocarcinoma (MA). Statistical significance was analyzed using Mann Whitney test. ( B ) Colon carcinomas harboring APC mutations were identified from the COSMIC database. Of the 35 samples that were found, five had multiple mutations in pyruvate metabolism genes that are predicted to be at least possibly damaging based on Polyphen2 in silico protein analysis. (***) – deletion; Polyphen2 prediction: (**) – probably damaging, (*) – possibly damaging, ( italics ) – benign. DOI: http://dx.doi.org/10.7554/eLife.22706.018
Article Snippet: Statistical analysis was performed using
Techniques: Gene Expression, MANN-WHITNEY, In Silico